Abstract

Periodic acid oxidation is applicable to compounds having two hydroxyl groups or hydroxyl and an amino group attached to adjacent carbon atoms and is characterized by the cleavage of the carbon-carbon bond. Carbonyl compounds in which the carbonyl group is adjacent to a second carbonyl or hydroxyl group are oxidized also In reactive compounds containing the amino-alcohol structure, the amino group may be primary or secondary. Oxidation has been reported to occur with a number of compounds which contain nitrogen, but possess no alpha-amino-alcohol structure.